Jacob Wesley Ulm, MD, PhD


Résumé and Annotated Summary of Publications


Professional summary: Harvard and MIT-trained (MD/PhD) physician-researcher with primary career focus in bioinformatics and advanced large dataset-driven drug discovery and global biomedical resource optimization; with additional experience in pharmaceutical research and repurposing, health and public policy, education and curriculum development, laboratory management, multilingual professional translation, technical writing and editing, and consulting


______________________________________________________HIGHLIGHTS_______________ _____   _____________________ _____   _

Language proficiencies (spoken)

Fluent (full professional proficiency, oral and written communication): Mandarin Chinese (experience as medical volunteer in China, hospital externship in Taiwan, presenter of popular online Mandarin lectures in genetics and molecular biology), Spanish, German

Advanced professional working proficiency (oral and written): Portuguese, French, Dutch, Italian

Basic conversational and written proficiency: Japanese, Russian, Ukrainian, Swedish, Danish, Farsi Persian

 (programming and scripting)

High-level proficiency with extensive professional working experience: Python (incl. essential  data science libraries such as pandas and numpy), SQL, R (certified); broad and specialized expertise for diverse applications across multiple platforms

Significant proficiency with some working experience: Perl, Pascal, Javascript, Matlab, HTML5


______________________________________________________EDUCATION________________ _____   _____________________ _____   __

HARVARD MEDICAL SCHOOL AND MIT                               Boston, MA        

Joint MD/PhD Program                                                                                              8/1996-5/2006

MD with PhD in Genetics and Gene Therapy


DUKE UNIVERSITY                                                                    Durham, NC

Bachelor of Science in Chemistry and Biochemistry (summa cum laude)         8/1992-5/1996



______________________________________________  WORK AND RESEARCH EXPERIENCE______________________         _____   ___ 

National Institutes of Health (US Dept of Health and Human Services)    Washington, D.C.



o   Application of multiple programming languages to critical tasks including Python, SQL, R, Perl, and Linux/Unix shell-scripting

o   Data warehousing and ETL (Google BigQuery and Amazon Redshift)

o   Software life cycle, development, and documentation

o   Solutions architecting and project management

o   GUI and Web deployment

o   UX and KPI optimization, including user research and engagement









CEDARS-SINAI MEDICAL CENTER/UCLA                                  Los Angeles, CA




MY TUTOR                                                                                Los Angeles, CA




THE WASHINGTON POST COMPANY                                                   Multi-site




INDEPENDENT CONTRACTOR                                                                          Multi-site




TRANSLATOR AND MULTILINGUAL PRESENTER                                     Multi-site







·        Resident physician successfully completed internship requirements and passed United States Medical Licensing Examination (USMLE) Step III on first attempt

o   Case report on zoonotic bacterial infection in post-renal transplant pediatric patients, published in J Pediatr Inf Dis

o   Roles as leader and teacher for various clinical teams


HARVARD MEDICAL SCHOOL/MIT                                             Boston, MA






HARVARD MEDICAL SCHOOL/MIT                                                               Boston, MA

DANA-FARBER CANCER INSTITUTE                                                                        9/2000-5/2001



NATURAL STANDARD CORPORATION                                                       Somerville, MA



·        Translator of scientific literature (peer-reviewed papers, abstracts, general documents) from German, Dutch, French, and Spanish to English


DUKE UNIVERSITY DEPT. OF CHEMISTRY                                                Durham, NC




DUKE UNIVERSITY MEDICAL CENTER                                                      Durham, NC




DUKE UNIVERSITY DEPT. OF CHEMISTRY                                                Durham, NC








OFFICE OF DR. RAYMOND ELLIS                                                         Vienna, VA




NATIONAL CANCER INSTITUTE, NIH                                                            6/1993-8/1993






Annotated Summary of Publications


Section 1:  Refereed and published papers, book chapters for specialized readership in biomedical field (not including PhD thesis dissertation)


“COVID-19 drug repurposing: Summary statistics on current clinical trials and promising untested candidates.” Ulm JW, Nelson SF. Transboundary and Emerging Diseases. Manuscript accepted for publication and in press. DOI: 10.1111/tbed.13710


“Complex determinants within the Moloney murine leukemia virus capsid modulate susceptibility of the virus to Fv1 and Ref1-mediated restriction.”  Ulm JW, Perron M, Sodroski J, Mulligan RC.  Virology. 2007 Jul 5;363(2):245-55.  


TRIM5alpha mediates the postentry block to N-tropic murine leukemia viruses in human cells.”  Perron MJ, Stremlau M, Song B, Ulm W, Mulligan RC, Sodroski J.  Proc Natl Acad Sci U S A. 2004 Aug 10;101(32):11827-32.


Authorship of two chapters (text and figures) on gene therapy principles, relevant modern techniques, and disease targets for Encyclopedia of Genetics, Genomics, Proteomics, and Bioinformatics, published September 2005 (John Wiley & Sons, Ltd.): Gene Therapy I:  Principles and Clinical Applications and Gene Therapy II:  Viral vectors and treatment modalities.


Co-authorship of Chapter 53, “Protein-based and gene therapies,” with contribution (text and figures) on gene therapy pharmaceuticals, vectors, disease targets, and novel modalities in textbook, Principles of Pharmacology: The Pathophysiologic Basis of Drug Therapy, edited by Dr. David Golan, Department of Pharmacology, Harvard Medical School; Lippincott Williams & Wilkins, April 2004


“Online Self-Report Data for Duchenne Muscular Dystrophy Confirms Natural History and Can Be Used to Assess for Therapeutic Benefits.” Wang RT, Silverstein Fadlon CA, Ulm JW, Jankovic I, Eskin A, Lu A, Rangel Miller V, Cantor RM, Li N, Elashoff R, Martin AS, Peay HL, Halnon N, Nelson SF. PLOS Currents Muscular Dystrophy. 2014 Oct 17. Edition 1. doi: 10.1371/currents.md.e1e8f2be7c949f9ffe81ec6fca1cce6a.


Acinetobacter bacteremia following a hamster bite in a child with history of kidney transplant.”  Azaran B, Puliyanda D, Ulm JW, Equils O.  J Pediatr Infect Dis, 2010;5(3);158-163. doi: 10.3233/JPI-2010-0252


Text mining-guided elucidation of high fidelity informatic proxy-based protocols to expedite drug repositioning and anticipate promising drug candidates for Duchenne muscular dystrophy: A pilot feasibility study” (report in progress)


Publication of detailed working Python computer language programming code on public Github site, as open-source software, for the BiomedScrape suite of text-mining and document comparison tools as well as the CorpusOptima project (developing large neutral pertinent semantic spaces for training advanced document comparison models) related to fellowship work; ongoing



Section 2: Conference papers for specialized audiences in biomedical field


“Development of the BiomedScrape Data-Mining Suite for Deep Semantic Structure-Based Drug Repurposing for DMD: A Pilot Feasibility Study”. Accepted abstract for 2018 American Society of Human Genetics annual meeting.


“Incorporation of Novel Categorical Data Parsing and Pattern-Recognition Tools in the Mining and Development of New Pharmacological Strategies for DMD Treatment and Management.” Abstract for 2016 UCLA Genetics Academic Retreat, American Society of Human Genetics, and Center for Duchenne Muscular Dystrophy annual meetings.


“Integrated Data-Aggregation and Mining Systems to Improve Detection of Meaningful Associations in DMD.” Abstract for 2015 UCLA Genetics Academic Retreat, American Society of Human Genetics, and Center for Duchenne Muscular Dystrophy annual meetings.


Online DuchenneConnect self-report data indicates Exon 44 skippable DMD patients have prolonged wheelchair free survival.” Abstract for 2014 UCLA Genetics Academic Retreat, American Society of Human Genetics, and Center for Duchenne Muscular Dystrophy annual meetings.


Herpesvirus Amplicon-based siRNA-expressing Vectors as a Therapeutic Strategy for Neurofibromatosis Type 1,” prize-winning (international 2nd prize) research proposal for 2003 International NF Research Competition for Graduate Students and Postdoctoral Fellows, National Neurofibromatosis Foundation (NNFF), with subsequent invitation to NNFF International Consortium for the Molecular Biology of NF1 and NF2, May 2004 in Aspen, Colorado.


AAV and HSV Amplicon-based si-RNA Expression Vectors as Therapeutic Modalities for Drug-Resistant Cancers.”  Abstract for 2004 International Society for Cell and Gene Therapy of Cancer (ISCGT) conference in Singapore, Cancer Gene Therapy 11, 859 - 860 (01 Dec 2004).


“Application of fast step-scan Fourier-transform infrared absorption-difference time-resolved spectroscopy (S2 FT-IR DA TRS) to examine association-dissociation kinetics of carbon monoxide and hemoglobin.” Abstract and oral presentation for American Chemical Society conference in North Carolina, spring 1996.





Section 3: Thesis dissertation and technical works for non-specialized audiences


PhD thesis dissertation:  Elucidation of retroviral capsid residues involved in modulation of murine and human cell post-entry restriction.  Approved November 2004, published in bound form (167 pages) April 2006, Graduate School of Arts and Sciences, Harvard Medical School.


Sole author of Fundamentals of Computer Science: A Study Guide, approx. 200-page problems workbook and guide for introductory computer science courses (algorithm design and Pascal programming), to accompany Great Ideas in Computer Science, textbook written by Dr. Alan Biermann of the Duke University Department of Computer Science; published at MIT Press, May 1996, and used at several universities nationwide.


Publication of research article on synthesis and kinetics of 3-deoxy-D-manno-octulosonic acid (KDO) and implications for novel gram-negative bacteria-specific antimicrobials in Vertices, Duke student science and technology magazine, Spring 1995 issue.